Abstract | BACKGROUND: Soft-tissue augmentation with permanent fillers can lead to severe granulomatous foreign-body reactions (GFBRs), but the immune pathomechanism of this complication is still unknown. We performed conventional histologic examination and immunostaining for plasmacytoid dendritic cells (pDCs) in skin sections from patients with GFBR to 4 permanent filler agents, which have been widely used in recent decades. METHODS: RESULTS: Grading of the inflammatory infiltrates observed histologically did not correlate with the clinical features of inflammation. Immunostaining for CD123 did not detect pDCs in 8 of 10 polyalkylimide gel, 1 of 2 polyacrylamide gel, and the 5 liquid injectable silicone biopsies. In contrast, all 4 HEMA/EMA biopsies contained collections of pDCs in lymphocytic infiltrates close to filler particles and adjacent sarcoidal granulomas. CONCLUSIONS: Our data suggest that pDCs contribute to the sarcoidal granulomas associated with injected HEMA/EMA. Recruited pDCs may exert their pro-inflammatory effects by the release of interferon-α at the site of these filler deposits.
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Authors | Jonathan A Kadouch, Wim Vos, Erik W P Nijhuis, Rick Hoekzema |
Journal | The American Journal of dermatopathology
(Am J Dermatopathol)
Vol. 37
Issue 2
Pg. 107-14
(Feb 2015)
ISSN: 1533-0311 [Electronic] United States |
PMID | 25406851
(Publication Type: Journal Article)
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Chemical References |
- Acrylic Resins
- Biocompatible Materials
- CD11c Antigen
- Gels
- IL3RA protein, human
- Interleukin-3 Receptor alpha Subunit
- Silicones
- polyacrylamide gels
- Polyhydroxyethyl Methacrylate
- hydroxyethyl methacrylate-ethyl methacrylate
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Topics |
- Acrylic Resins
(adverse effects)
- Adult
- Aged
- Biocompatible Materials
(administration & dosage, adverse effects)
- Biopsy
- CD11c Antigen
(analysis)
- Cosmetic Techniques
(adverse effects)
- Dendritic Cells
(drug effects, immunology)
- Female
- Gels
- Granuloma, Foreign-Body
(chemically induced, immunology, pathology)
- Humans
- Immunohistochemistry
- Injections, Intradermal
- Interleukin-3 Receptor alpha Subunit
(analysis)
- Male
- Middle Aged
- Polyhydroxyethyl Methacrylate
(adverse effects, analogs & derivatives)
- Predictive Value of Tests
- Silicones
(adverse effects)
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