Abstract | BACKGROUND: METHODS AND RESULTS: CONCLUSIONS: A drug-coated balloon catheter using NFκB decoy oligodeoxynucleotides significantly inhibited the development of neointimal hyperplasia in rabbits. The present study indicates the possibility of a novel therapeutic option to prevent restenosis after angioplasty.
|
Authors | Takashi Miyake, Shinya Ihara, Tetsuo Miyake, Yusuke Tsukada, Hajime Watanabe, Hiroaki Matsuda, Hideki Kiguchi, Hiroyuki Tsujimoto, Hironori Nakagami, Ryuichi Morishita |
Journal | Circulation. Cardiovascular interventions
(Circ Cardiovasc Interv)
Vol. 7
Issue 6
Pg. 787-96
(Dec 2014)
ISSN: 1941-7632 [Electronic] United States |
PMID | 25406205
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © 2014 American Heart Association, Inc. |
Chemical References |
- Coated Materials, Biocompatible
- NF-kappa B
- Oligodeoxyribonucleotides
|
Topics |
- Angioplasty, Balloon
(adverse effects, instrumentation)
- Animals
- Carotid Artery Injuries
(diagnosis, etiology, genetics, metabolism, therapy)
- Coated Materials, Biocompatible
- Constriction, Pathologic
- Coronary Vessels
(metabolism, pathology)
- Disease Models, Animal
- Gene Expression Regulation
- Male
- NF-kappa B
(genetics, metabolism)
- Nanoparticles
- Neointima
- Oligodeoxyribonucleotides
(administration & dosage)
- Rabbits
- Signal Transduction
- Time Factors
- Vascular Access Devices
|