Abstract | BACKGROUND: Intraoperative anaphylaxis is a rare but serious occurrence, often triggered by neuromuscular-blocking drugs (NMBDs). Previous reports suggest that the rates of anaphylaxis may be greater for rocuronium than for other NMBDs, but imprecise surrogate metrics for new patient exposures to NMBDs complicate interpretation. METHODS: This was a retrospective, observational cohort study of intraoperative anaphylaxis to NMBDs at two hospitals between 2006 and 2012. Expert anesthetic and immunologist collaborators investigated all referred cases of intraoperative anaphylaxis where NMBDs were administered and identified those where a NMBD was considered responsible. New patient exposures for each NMBD were extracted from electronic anesthetic records compiled during the same period. Anaphylaxis rates were calculated for each NMBD using diagnosed anaphylaxis cases as the numerator and the number of new patient exposures as the denominator. RESULTS: CONCLUSIONS:
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Authors | Jeffrey I Reddy, Peter J Cooke, Johan M van Schalkwyk, Jacqueline A Hannam, Penny Fitzharris, Simon J Mitchell |
Journal | Anesthesiology
(Anesthesiology)
Vol. 122
Issue 1
Pg. 39-45
(Jan 2015)
ISSN: 1528-1175 [Electronic] United States |
PMID | 25405395
(Publication Type: Comparative Study, Journal Article, Observational Study)
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Chemical References |
- Androstanols
- Neuromuscular Nondepolarizing Agents
- Atracurium
- Succinylcholine
- Rocuronium
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anaphylaxis
(epidemiology, etiology)
- Androstanols
(adverse effects)
- Atracurium
(adverse effects)
- Causality
- Cohort Studies
- Female
- Humans
- Incidence
- Intraoperative Complications
(epidemiology)
- Male
- Middle Aged
- Neuromuscular Blockade
(adverse effects)
- Neuromuscular Nondepolarizing Agents
(adverse effects)
- New Zealand
(epidemiology)
- Retrospective Studies
- Rocuronium
- Succinylcholine
(adverse effects)
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