Abstract | OBJECTIVE: STUDY DESIGN: Double blind randomized controlled trial. PLACE AND DURATION OF STUDY: Dermatology OPD, Military Hospital, Rawalpindi, from July 2008 to July 2009. METHODOLOGY: Patients aged above 10 years, diagnosed with PR, were randomly assigned to two groups of 30 each to receive either clarithromycin or similar-looking placebo for one week. Neither the patient nor the treating physician knew to which group the patient belonged. Patients were assessed at 1, 2, 4 and 6 weeks after presentation and compared for complete, partial or no response. RESULTS: Among the 60 patients, no significant difference was found between the two groups at 2 weeks after presentation (p = 0.598). In the placebo group, complete response was seen in 20 (66.7%), partial response in 3 (10.0%) while no response was seen in 7 (23.3%). In clarithromycin group, there was complete response in 23 (76.7%), partial response in 3 (10.0%) and no response in 4 (13.3%) patients. CONCLUSION:
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Authors | Najia Ahmed, Nadia Iftikhar, Uzma Bashir, Syed Dilawar Abbas Rizvi, Zafar Iqbal Sheikh, Amir Manzur |
Journal | Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
(J Coll Physicians Surg Pak)
Vol. 24
Issue 11
Pg. 802-5
(Nov 2014)
ISSN: 1681-7168 [Electronic] Pakistan |
PMID | 25404436
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Clarithromycin
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Topics |
- Administration, Oral
- Adult
- Aged
- Anti-Bacterial Agents
(therapeutic use)
- Clarithromycin
(therapeutic use)
- Double-Blind Method
- Female
- Humans
- Male
- Pityriasis Rosea
(diagnosis, drug therapy)
- Treatment Outcome
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