Hypoglycemic and anticoagulant effects of tetrapeptide Pro-Gly-Pro-Leu in hypercholesterolemia.

Abstract

In rats with experimental hypercholesterolemia, 7-fold intranasal administration of the peptide Pro-Gly-Pro-Leu in a dose of 200 μg/kg body weight prevented the increase in blood glucose level and produced an anticoagulant effect.

• Authors: T A Shubina, M E Grigor'eva, L A Lyapina, T Yu Obergan, N F Myasoedov, L A Andreeva
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 158 Issue 1 Pg. 30-3 (Nov 2014) ISSN: 1573-8221 [Electronic] United States
• PMID: 25403391 (Publication Type: Journal Article)

Chemical References

• Anticoagulants
• Blood Glucose
• Hypoglycemic Agents
• Oligopeptides
• prolyl-glycyl-prolyl-leucine

Topics

• Animals
• Animals, Outbred Strains
• Anticoagulants (administration & dosage, pharmacology)
• Blood Glucose
• Drug Evaluation, Preclinical
• Hypercholesterolemia (blood)
• Hypoglycemic Agents (administration & dosage, pharmacology)
• Male
• Oligopeptides (administration & dosage, pharmacology)