Papillary thyroid cancer in a struma ovarii: a report of a rare case.

Abstract

After removal of an ovarian mass in a 43-year-old woman, a struma ovarii was diagnosed. Within this teratoma, a papillary thyroid cancer was found. The tumor was negative for BRAF, NRAS, KRAS, PIK3CA and c-KIT mutations on molecular analysis. Thyroid function and morphology were normal. Thyroidectomy, L-T4 TSH-suppressive therapy and rhTSH-induced radioiodine ablation were performed. So far, the follow-up has been favorable. This is the first case of thyroid cancer in a struma ovarii in which mutations of PIK3CA exons 9 and 20, and c-KIT exons 9, 11 and 13 have been evaluated and the third in which ablation has been performed under rhTSH. The prognosis of patients with thyroid cancer in a struma ovarii is generally poor. In our patient, as in those who undergo ablative radioactive iodine therapy, this was not the case.

• Authors: Eleonora Monti, Lorenzo Mortara, Simonetta Zupo, Mariella Dono, Francesco Minuto, Mauro Truini, Mehrdad Naseri, Massimo Giusti
• Journal: Hormones (Athens, Greece) (Hormones (Athens)) 2015 Jan-Mar Vol. 14 Issue 1 Pg. 154-9 ISSN: 2520-8721 [Electronic] Switzerland
• PMID: 25402391 (Publication Type: Case Reports, Journal Article)

Chemical References

• Iodine Radioisotopes

Topics

• Adult
• Carcinoma, Papillary (pathology, radiotherapy, surgery)
• Female
• Humans
• Iodine Radioisotopes (therapeutic use)
• Neoplasms, Multiple Primary (pathology, radiotherapy, surgery)
• Ovarian Neoplasms (pathology, surgery)
• Struma Ovarii (pathology, surgery)
• Thyroid Neoplasms (pathology, radiotherapy, surgery)
• Thyroidectomy
• Treatment Outcome