Abstract | PURPOSE: MATERIAL AND METHODS: 260 patients with stages I to IV between 2008 and 2013 were recruited in this study and same number healthy persons were used as control. OPN-66 T/G, -156 G/GG and -443 C/T variants were genotyped using DNA from blood lymphocytes. Chi-square test and a Fisher's exact test were used to analyze the genotype distribution between healthy subjects and patients, and further its distribution among TNM stages and incidence metastasis in patients. RESULTS: For the variant at nt- 443 (CC), there was a significant difference between the number of patients with stage IV and those with all other stages of ICC (P < 0.01). Patients with -443 (CC) variant had significant higher incidence of lymph and distant metastasis development compared to other genotypes. For the variant at nt- 443 (CT), there was a significant difference between the number of ICC patients with stage III + IV and those with stage I + II (P < 0.01). The survival rates for ICC patients with the C/C genotype were significantly lower than for patients with the other two genotypes (C/T, T/T). CONCLUSION: OPN -443 C/T polymorphism is a potential predictive marker of metastasis and poor prognosis in ICC patients.
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Authors | Xiang-Qian Zhao, Huan-Xian Ma, Mao-Sheng Su, Lei He |
Journal | International journal of clinical and experimental pathology
(Int J Clin Exp Pathol)
Vol. 7
Issue 10
Pg. 6914-21
( 2014)
ISSN: 1936-2625 [Electronic] United States |
PMID | 25400775
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- SPP1 protein, human
- Osteopontin
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Topics |
- Adult
- Aged
- Bile Duct Neoplasms
(genetics, mortality, pathology)
- Bile Ducts, Intrahepatic
(pathology)
- Case-Control Studies
- Chi-Square Distribution
- Cholangiocarcinoma
(genetics, mortality, secondary)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Kaplan-Meier Estimate
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Staging
- Osteopontin
(genetics)
- Phenotype
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Risk Factors
- Young Adult
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