Correlation between the antiviral activity of acyclic and carbocyclic adenosine analogues in murine L929 cells and their inhibitory effect on L929 cells S-adenosylhomocysteine hydrolase.

Abstract

For a series of acyclic and carbocyclic adenosine analogues, a close correlation was found between their inhibitory effect on murine L929 cell S-adenosylhomocysteine (AdoHcy) hydrolase and their inhibitory effects on the replication of vaccinia virus and vesicular stomatitis virus (r: 0.993 and 0.988, respectively). In terms of their increasing inhibitory action against both virus replication and AdoHcy hydrolase activity the compounds ranked as follows: (S)-9-(2,3-dihydroxypropyl)adenine less than (RS)-3-adenin-9-yl-2-hydroxypropanoic acid (isobutyl ester) less than 3-deazaneplanocin A approximately carbocyclic 3-deazaadenosine less than adenosine dialdehyde less than neplanocin A. These findings point to AdoHcy hydrolase as the target for the antiviral action of these adenosine analogues.

• Authors: M Cools, E de Clercq
• Journal: Biochemical pharmacology (Biochem Pharmacol) Vol. 38 Issue 7 Pg. 1061-7 (Apr 01 1989) ISSN: 0006-2952 [Print] England
• PMID: 2539815 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• aristeromycin
• 9-(2,3-dihydroxypropyl)adenine
• neplanocin A
• 3-adenin-9-yl-2-hydroxypropanoic acid isobutyl ester
• Hydrolases
• Adenosylhomocysteinase
• Adenine
• Adenosine

Topics

• Adenine (analogs & derivatives, pharmacology)
• Adenosine (analogs & derivatives, pharmacology)
• Adenosylhomocysteinase
• Animals
• Antiviral Agents
• Cell Line (drug effects)
• Fibroblasts (drug effects)
• Hydrolases (antagonists & inhibitors)
• Kinetics
• Mice
• Vaccinia virus (drug effects, enzymology)
• Vesicular stomatitis Indiana virus (drug effects, enzymology)
• Virus Replication (drug effects)