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Stimulation of estrogen receptor mRNA levels in MCF-7 cells by herpes simplex virus infection.

Abstract
Infection of estrogen-responsive cells (MCF-7) with herpes simplex virus type 1 or 2 stimulates expression of the estrogen receptor message. Experiments on infection with the mutant virus, tsK, together with transfection studies implicate the virion protein, Vmw65, in the response. Cellular protein synthesis is essential for estrogen receptor mRNA expression.
AuthorsE A Offord, R E Leake, J C Macnab
JournalJournal of virology (J Virol) Vol. 63 Issue 5 Pg. 2388-91 (May 1989) ISSN: 0022-538X [Print] United States
PMID2539527 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • RNA, Messenger
  • Receptors, Estrogen
  • Viral Proteins
  • Cycloheximide
Topics
  • Blotting, Northern
  • Breast Neoplasms (genetics)
  • Cycloheximide (pharmacology)
  • Gene Expression Regulation (drug effects)
  • Herpes Simplex (genetics)
  • Humans
  • RNA, Messenger (genetics)
  • Receptors, Estrogen (genetics)
  • Simplexvirus
  • Tumor Cells, Cultured
  • Viral Proteins (physiology)

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