Comparison of pulmonary involvement between patients expressing anti-PL-7 and anti-Jo-1 antibodies.

Abstract

Anti-PL-7 is an anti-tRNA synthetase antibody, and interstitial lung disease (ILD) is the most frequent complication of anti-PL-7-associated antisynthetase syndrome. However, the features of ILD have not been fully elucidated. The present study retrospectively compares 7 and 15 patients who were positive for anti-PL-7 and anti-Jo-1 antibodies, respectively. The features of ILD did not significantly differ between the two groups, but the ratio of lymphocytes in bronchoalveolar lavage fluid was higher in the Jo-1 than in the PL-7 group. High-resolution computed tomography revealed nonspecific interstitial pneumonia in all patients in the PL-7 group and organizing pneumonia in four of the 15 patients in the Jo-1 group. These findings suggest that pulmonary complications slightly differ between patients expressing anti-PL-7 and anti-Jo-1 antibodies. Further studies are required to clarify the features of ILD associated with PL-7.

• Authors: Masaomi Tomonaga, Noriho Sakamoto, Yuji Ishimatsu, Tomoyuki Kakugawa, Tatsuhiko Harada, Shota Nakashima, Atsuko Hara, Shintaro Hara, Yoshihiro Horai, Atsushi Kawakami, Hiroshi Mukae, Shigeru Kohno
• Journal: Lung (Lung) Vol. 193 Issue 1 Pg. 79-83 (Feb 2015) ISSN: 1432-1750 [Electronic] United States
• PMID: 25394672 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Antinuclear
• Biomarkers
• Jo-1 antibody
• Threonine-tRNA Ligase

Topics

• Adult
• Antibodies, Antinuclear (blood)
• Biomarkers (blood)
• Cryptogenic Organizing Pneumonia (blood, diagnosis, etiology, immunology)
• Female
• Humans
• Lung (diagnostic imaging)
• Lung Diseases, Interstitial (blood, diagnosis, etiology, immunology)
• Male
• Middle Aged
• Myositis (blood, complications, diagnosis, immunology)
• Predictive Value of Tests
• Retrospective Studies
• Threonine-tRNA Ligase (immunology)
• Tomography, X-Ray Computed