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Fifteen years of kidney biopsies in children: a single center in Egypt.

Abstract
This study retrospectively investigates the indications and results of renal biopsy in children to determine the patterns of childhood kidney disease in a single tertiary children's hospital in Egypt. We included all the patients who underwent ultrasound-guided renal biopsy from 1998 to 2012. All the kidney biopsies were studied under light microscopy, while immunofluorescence and electron microscopy were performed when indicated. A total of 1246 renal biopsies were performed over 15 years, on 1096 patients. The mean age of the patients at the time of biopsy was 9.2±3.7 years. The main indication for a biopsy was the steroid-resistant nephrotic syndrome (n=354, 28.4%), followed by the atypical nephrotic syndrome (n=250, 20.1%), and renal abnormalities in the systemic diseases (n=228, 18.3 %). In the 1226 pathologically diagnosed specimens, primary glomerulonephritis was the most common finding (n=826, 67.4%), followed by secondary glomerulonephritis (n=238, 19.4%). The most common causes of primary glomerulonephritis were Minimal Change Disease (MCD) (n=267, 21.8%), diffuse proliferative glomerulonephritis (n=188, 15. 3%), and focal proliferative glomerulonephritis (n=164, 13.3%). Lupus nephritis (n=209, 17%) was the most common cause of secondary glomerulonephritis. We conclude that the steroid-resistant nephrotic syndrome was the most frequent indication for biopsy and minimal change disease was the most common histopathological finding in our population.
AuthorsAshraf Bakr, Riham Eid, Amr Sarhan, Ayman Hammad, Ahmed Mahmoud El-Refaey, Atef El-Mougy, Mohammed Magdy Zedan, Fatma ElHusseini, Ashraf Abd El-Rahman
JournalSaudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (Saudi J Kidney Dis Transpl) Vol. 25 Issue 6 Pg. 1321-7 (Nov 2014) ISSN: 1319-2442 [Print] Saudi Arabia
PMID25394460 (Publication Type: Journal Article)
Topics
  • Adolescent
  • Age Factors
  • Biopsy
  • Child
  • Child, Preschool
  • Egypt (epidemiology)
  • Female
  • Fluorescent Antibody Technique
  • Hospitals, Pediatric
  • Humans
  • Infant
  • Kidney (pathology, ultrastructure)
  • Kidney Diseases (diagnosis, epidemiology, pathology)
  • Male
  • Microscopy, Electron
  • Microscopy, Fluorescence
  • Nephrosis, Lipoid (diagnosis, pathology)
  • Nephrotic Syndrome (congenital, diagnosis, pathology)
  • Predictive Value of Tests
  • Retrospective Studies
  • Tertiary Care Centers

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