Hb Monroe or alpha 2 beta 230(B12)Arg----Thr, a variant associated with beta-thalassemia due to A G----C substitution adjacent to the donor splice site of the first intron.

• Authors: J M Gonzalez-Redondo, T A Stoming, F Kutlar, A Kutlar, H Hu, J B Wilson, T H Huisman
• Journal: Hemoglobin (Hemoglobin) Vol. 13 Issue 1 Pg. 67-74 ( 1989) ISSN: 0363-0269 [Print] England
• PMID: 2539344 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA Probes
• Hemoglobins, Abnormal
• hemoglobin Monroe
• DNA Restriction Enzymes

Topics

• Adolescent
• Black People (genetics)
• DNA Mutational Analysis
• DNA Probes (analysis)
• DNA Restriction Enzymes
• Female
• Gene Rearrangement
• Hemoglobins, Abnormal (genetics, isolation & purification)
• Humans
• Introns
• Multigene Family
• Mutation
• Thalassemia (blood, genetics)
• United States