Treatment of malignant ascites and pleurisy by a streptococcal preparation OK-432 with fresh frozen plasma--a mechanism of polymorphonuclear leukocyte (PMN) accumulation.

Abstract

A single injection of a streptococcal preparation, OK-432, with fresh frozen plasma (FFP) (or fresh human serum) into the peritoneal or pleural cavity for the treatment of malignant ascites or pleurisy resulted in a complete reduction of ascitic fluid or pleural effusion in 5 out of 11 patients. FFP was used a further source of complement for the effective accumulation of antitumor polymorphonuclear leukocytes (PMNs) by complement-derived chemotactic factors in the cavity. C5a increased in the fluids 3-9 h after the injection and preceded a massive increase in PMNs. C1 inhibitor (C1INH) and C3b inactivator (C3bINA) decreased in several cases 6 h after the treatment. Chemotactic arachidonic acid metabolites, thromboxane B2(TXB2) as a characteristics of TXA2, and leukotriene B4(LTB4) also increased at the same time even in cases where C5a changed only minimally, and may play a role in accumulating antitumor PMNs in the cavity.

• Authors: H Kato, Y Yamamura, R Kin, M Tanigawa, H Sano, M Inoue, S Sugino, M Kondo
• Journal: International journal of immunopharmacology (Int J Immunopharmacol) Vol. 11 Issue 2 Pg. 117-28 ( 1989) ISSN: 0192-0561 [Print] England
• PMID: 2539336 (Publication Type: Journal Article)

Chemical References

• Biological Products
• Complement C5
• Leukotriene B4
• Picibanil
• Thromboxane B2
• Complement C5a

Topics

• Adult
• Aged
• Aged, 80 and over
• Ascites (immunology, therapy)
• Biological Products (therapeutic use)
• Complement Activation
• Complement C5 (analysis)
• Complement C5a
• Female
• Freezing
• Humans
• Immunization, Passive
• Leukotriene B4 (analysis)
• Male
• Middle Aged
• Neoplasms (therapy)
• Neutrophils (immunology)
• Picibanil (adverse effects, therapeutic use)
• Pleurisy (immunology, therapy)
• Thromboxane B2 (analysis)