Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: Mice subjected to chronic constriction injury (CCI) were tested for mechanical and cold allodynia after administration of the MAGL inhibitor, JZL184, or the non-selective COX inhibitor diclofenac. Then, both drugs were co-administered at fixed dose proportions of 1:3, 1:1 and 3:1, based on their ED50 values. PGs, endocannabinoids and related lipids were quantified in lumbar spinal cord. KEY RESULTS: CONCLUSIONS AND IMPLICATIONS: Combining COX and MAGL inhibition is a promising therapeutic approach for reducing neuropathic pain with minimal side effects.
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Authors | Molly S Crowe, Emma Leishman, Matthew L Banks, Ramesh Gujjar, Anu Mahadevan, Heather B Bradshaw, Steven G Kinsey |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 172
Issue 7
Pg. 1700-12
(Apr 2015)
ISSN: 1476-5381 [Electronic] England |
PMID | 25393148
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © 2014 The British Pharmacological Society. |
Chemical References |
- Analgesics
- Benzodioxoles
- Cannabinoid Receptor Antagonists
- Cyclooxygenase Inhibitors
- Eicosanoids
- Endocannabinoids
- Fatty Acids
- JZL 184
- Piperidines
- Pyrazoles
- Diclofenac
- Prostaglandin-Endoperoxide Synthases
- Monoacylglycerol Lipases
- Rimonabant
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Topics |
- Analgesics
(therapeutic use)
- Animals
- Benzodioxoles
(therapeutic use)
- Cannabinoid Receptor Antagonists
(pharmacology)
- Cyclooxygenase Inhibitors
(therapeutic use)
- Diclofenac
(therapeutic use)
- Drug Synergism
- Drug Therapy, Combination
- Eicosanoids
(metabolism)
- Endocannabinoids
(metabolism)
- Fatty Acids
(metabolism)
- Hyperalgesia
(drug therapy, metabolism)
- Male
- Mice, Inbred C57BL
- Monoacylglycerol Lipases
(antagonists & inhibitors)
- Neuralgia
(drug therapy, metabolism)
- Piperidines
(pharmacology, therapeutic use)
- Prostaglandin-Endoperoxide Synthases
- Pyrazoles
(pharmacology)
- Rimonabant
- Spinal Cord
(metabolism)
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