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Effect of Laparoscopic Roux-en-Y Gastric Bypass Surgery on Obstructive Sleep Apnea in a Chinese Population with Obesity and T2DM.

AbstractBACKGROUND:
Bariatric surgery has been reported to be an effective treatment for obstructive sleep apnea (OSA). However, this evidence was not enough for different populations. Thus, we conducted a follow-up study to evaluate the effect of bariatric surgery on OSA in a Chinese population with obesity and type 2 diabetes mellitus (T2DM).
METHODS:
From May 2011 to March 2014, 72 consecutive subjects with obesity and T2DM were recruited for this study. Before and at least 6 months after the laparoscopic Roux-en-Y gastric bypass (LYGB) surgery, all subjects were asked to undergo a polysomnography test. During the sleep center visit, anthropometric characteristic data, blood samples, and sleep questionnaires were collected.
RESULTS:
In total, 44 Chinese participants with OSA were included in the study. Compared with baseline data, the postoperative anthropometric characteristics, blood measurements, and sleep recording data, such as weight, apnea hypopnea index (AHI), and insulin resistance index, differed significantly (p < 0.001). The change in AHI was correlated significantly with preoperative weight (r = 0.298, p < 0.05), preoperative AHI (r = 0.729, p < 0.001), preoperative waist circumference (r = 0.307, p < 0.05), and preoperative insulin resistance (IR) index (r = -0.301, p < 0.05). Postoperative AHI was correlated significantly with age (r = 0.039, p = 0.039) and preoperative AHI (r = 0.445, p = 0.002), and the following prediction model was generated: log10 (postoperative AHI) = 0.626 × log10 (preoperative AHI) +0.010 × age -0.581.
CONCLUSIONS:
Our findings indicate that LYGB could be an effective therapeutic intervention in the management of OSA for patients with both obesity and T2DM, and the preoperative AHI and age might be important factors that influence the effort of LYGB.
AuthorsJianyin Zou, Pin Zhang, Haoyong Yu, Jianzhong Di, Xiaodong Han, Shankai Yin, Hongliang Yi
JournalObesity surgery (Obes Surg) Vol. 25 Issue 8 Pg. 1446-53 (Aug 2015) ISSN: 1708-0428 [Electronic] United States
PMID25392079 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adult
  • Aged
  • Body Mass Index
  • China (epidemiology)
  • Diabetes Mellitus, Type 2 (complications, epidemiology, surgery)
  • Female
  • Follow-Up Studies
  • Gastric Bypass (methods)
  • Humans
  • Insulin Resistance
  • Laparoscopy (methods)
  • Male
  • Middle Aged
  • Obesity (complications, epidemiology, surgery)
  • Polysomnography
  • Sleep (physiology)
  • Sleep Apnea, Obstructive (complications, epidemiology, surgery)
  • Surveys and Questionnaires
  • Treatment Outcome
  • Young Adult

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