Echographic localization of periocular Carboplatin for treatment of advanced retinoblastoma.

Abstract

PURPOSE:

To study ocular ultrasonography as a means to effectively localize periocular carboplatin in patients with advanced retinoblastoma.

METHODS:

In a cases series, seven patients diagnosed with advanced retinoblastoma refractory to standard chemotherapy were treated with two to four periocular carboplatin injections. Echographic images were obtained before and after injection.

RESULTS:

The periocular carboplatin depot was a discrete homogeneous structure with lower internal reflectivity than the surrounding orbital tissue. The mean maximal juxtascleral height of the drug depot ± SD was 3.3 ±1.4 mm and was located directly posterior to the area of maximal intraocular tumor thickness in all seven patients. Moderate shadowing from calcification was present in one patient. Five patients had a pattern of a thinner pocket of drug visible after subsequent injections.

CONCLUSIONS:

Echography is a useful technique to study novel periocular drug delivery. It effectively images the drug in relation to the intraocular tumor, confirming the most effective drug placement for these resistant tumors.

• Authors: Colleen M Cebulla, Armando Alegret, Fiona J Ehlies, R Prince Davis 2nd, Ditte J Hess, Timothy G Murray, Echography Study Group
• Journal: Retinal cases & brief reports (Retin Cases Brief Rep) Vol. 3 Issue 1 Pg. 4-7 ( 2009) ISSN: 1935-1089 [Print] United States
• PMID: 25390825 (Publication Type: Journal Article)