Long-term results of oxybutynin use in treating facial hyperhidrosis.

Facial hyperhidrosis can lead to serious emotional distress. Video-assisted thoracic sympathectomy resolves symptoms effectively, though it may be associated with compensatory hyperhidrosis, which may be more common in patients undergoing resection of the second thoracic ganglion. Oxybutynin has been used as a pharmacological approach to facial hyperhidrosis but the long-term results of this treatment are unclear.
To evaluate the use of low oxybutynin doses in facial hyperhidrosis patients for at least six months.
61 patients were monitored for over six months and assessed according to the following variables: impact of hyperhidrosis on quality of life (QOL) before treatment and after six weeks, evolution of facial hyperhidrosis after six weeks and at the last consultation, complaints of dry mouth after six weeks and on last return visit, and improvement at other hyperhidrosis sites.
Patients were monitored for 6 to 61 months (median=17 months). Thirty-six (59%) were female. Age ranged from 17-74 (median:45). Pre-treatment QOL was poor/very poor in 96.72%. After six weeks, 100% of patients improved QOL. Comparing results after six weeks and on the last visit, 91.8% of patients maintained the same category of improvement in facial hyperhidrosis, 3.3% worsened and 4.9% improved. Dry mouth complaints were common but not consistent throughout treatment. More than 90% of patients presented moderate/great improvement at other hyperhidrosis sites.
Patients who had a good initial response to treatment maintained a good response long-term, did not display tachiphylaxis and experienced improvement on other hyperhidrosis sites.
AuthorsNelson Wolosker, Marcelo Passos Teivelis, Mariana Krutman, Taiz Pereira Dozono de Almeida Campbell, Paulo Kauffman, José Ribas de Campos, Pedro Puech-Leão
JournalAnais brasileiros de dermatologia (An Bras Dermatol) 2014 Nov-Dec Vol. 89 Issue 6 Pg. 912-6 ISSN: 1806-4841 [Electronic] Brazil
PMID25387496 (Publication Type: Evaluation Studies, Journal Article)
Chemical References
  • Mandelic Acids
  • Muscarinic Antagonists
  • oxybutynin
  • Adolescent
  • Adult
  • Aged
  • Face
  • Female
  • Humans
  • Hyperhidrosis (drug therapy)
  • Male
  • Mandelic Acids (administration & dosage)
  • Middle Aged
  • Muscarinic Antagonists (administration & dosage)
  • Quality of Life
  • Time Factors
  • Treatment Outcome
  • Xerostomia (chemically induced)
  • Young Adult

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