Lower facial remodeling with botulinum toxin type A for the treatment of masseter hypertrophy.

Abstract

BACKGROUND:

Masseter hypertrophy has been treated with botulinum toxin injections because of esthetic complaints especially in Asians.

OBJECTIVES:

The goal of the present study was to evaluate the efficacy of abobotulin toxin use in masseter hipertrophy treatment in Brazilians.

METHODS:

Ten Brazilian female patients with masseter hypertrophy were subjected to injections of 90U of abobotulinum toxin A applied on each side respecting the safety zone stabilished in literature and were followed up for 24 weeks.

RESULTS:

When analyzing the coefficients between measures of middle and lower third of the face obtained from standardized photographs, an increase was observed, with statistical significance at 2 weeks (p=0.005) and 12 weeks (p=0.001). The progression of lower third reduction was 3.94%, 5.26%, 11.99%, and 5.47% (2, 4, 12, and 24 weeks respectively). All patients showed improvement in bruxism after treatment. Observed adverse effects were masticatory fatigue, smile limitation, and smile asymmetry.

CONCLUSION:

The use of abobotulinum toxin A for masseter hypertrophy is effective in Brazilians and reached its maximum effect of facial thinning at 12 weeks. Smile limitation had a higher incidence compared to that reported in the literature and may result from risorius muscle blockage caused by toxin dissemination. Despite its side effects, 80% of the patients would like to repeat the treatment.

• Authors: Fernanda Homem de Mello de Souza Klein, Fabiane Mulinari Brenner, Maurício Shigeru Sato, Fernanda Manfron Batista Rosas Robert, Karin Adriane Helmer
• Journal: Anais brasileiros de dermatologia (An Bras Dermatol) 2014 Nov-Dec Vol. 89 Issue 6 Pg. 878-84 ISSN: 1806-4841 [Electronic] Spain
• PMID: 25387491 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Neuromuscular Agents
• Botulinum Toxins, Type A

Topics

• Adult
• Botulinum Toxins, Type A (therapeutic use)
• Brazil (ethnology)
• Face
• Female
• Humans
• Hypertrophy (drug therapy)
• Injections, Intramuscular
• Masseter Muscle (abnormalities, drug effects)
• Neuromuscular Agents (therapeutic use)
• Smiling (physiology)
• Time Factors
• Treatment Outcome