The self-assembly of anticancer camptothecin-dipeptide nanotubes: a minimalistic and high drug loading approach to increased efficacy.

Abstract

20-(S)-Camptothecin (CPT)-conjugated dipeptides are reported that preassemble into nanotubes with diameters ranging from 80-120 nm. These nanoassemblies maintain a high (∼47 %) drug loading and exhibit greater drug stability (i.e., resistance to lactone hydrolysis), and consequently greater efficacy against several human cancer cells (HT-29, A549, H460, and H23) in vitro compared with the clinically used prodrug irinotecan. A key and defining feature of this system is the use of the CPT-conjugated dipeptide as both the drug and precursor to the nanostructured carrier, which simplifies the overall fabrication process.

• Authors: Se Hye Kim, Jonah A Kaplan, Yuan Sun, Aileen Shieh, Hui-Lung Sun, Carlo M Croce, Mark W Grinstaff, Jon R Parquette
• Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (Chemistry) Vol. 21 Issue 1 Pg. 101-5 (Jan 02 2015) ISSN: 1521-3765 [Electronic] Germany
• PMID: 25384556 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antineoplastic Agents, Phytogenic
• Dipeptides
• Drug Carriers
• Prodrugs
• Camptothecin

Topics

• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Camptothecin (chemistry, pharmacology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Dipeptides (chemistry)
• Drug Carriers (chemistry)
• HT29 Cells
• Humans
• Microscopy, Fluorescence
• Nanomedicine
• Nanotubes (chemistry)
• Prodrugs (chemistry, pharmacology)