Does somatostatin-14 have an impact on gastric fistula after laparoscopic sleeve gastrectomy?

The main complications following laparoscopic sleeve gastrectomy (LSG) is gastric fistula (GF). Gastric fistula is a rare but serious complication (affecting 2 % of LSGs). Somatostatin-14 and its analogs are mainly used in the prevention and curative treatment of digestive fistulas. These compounds inhibit secretions in the pancreas, stomach, and small intestine. Treatment with somatostatin-14 increases the spontaneous closure rate and reduces the closure time of postoperative digestive fistulas. However, the impact of somatostatin-14 on GF after LSG has not been studied. We report on a prospective, non-randomized, single-center, case-matched study of patients receiving somatostatin-14 after a post-LSG GF was discovered. Our results suggest that use of somatostatin-14 is associated with a shorter length of hospital stay and (perhaps) a shorter treatment period.
AuthorsLionel Rebibo, Flavien Prevot, Abdennaceur Dhahri, Jean-Marc Regimbeau
JournalObesity surgery (Obes Surg) Vol. 25 Issue 2 Pg. 377-80 (Feb 2015) ISSN: 1708-0428 [Electronic] United States
PMID25381116 (Publication Type: Journal Article)
Chemical References
  • Somatostatin
  • Adult
  • Case-Control Studies
  • Female
  • Gastrectomy (adverse effects, methods)
  • Gastric Fistula (epidemiology, etiology, prevention & control)
  • Humans
  • Laparoscopy (adverse effects, methods)
  • Length of Stay
  • Male
  • Middle Aged
  • Obesity, Morbid (drug therapy, epidemiology, surgery)
  • Postoperative Complications (epidemiology, etiology, prevention & control)
  • Prospective Studies
  • Retrospective Studies
  • Somatostatin (therapeutic use)
  • Young Adult

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