Abstract | PURPOSE: METHODS: Using a nested case-control study design, we examined prediagnostic urinary concentrations of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite, in 153 gastric cancer cases and 306 matched controls within the Shanghai Women's Health Study. Conditional logistic regression adjusted for potential risk factors was used to estimate odds ratios ( ORs) and 95% confidence intervals (95% CIs). RESULTS: Urinary 1-OHPG concentrations were slightly higher among cases than controls, with medians of 0.29 μmol/mol Cr (interquartile range, 0.16-0.48) and 0.24 μmol/mol Cr (interquartile range, 0.12-0.45), respectively. Increasing concentrations of 1-OHPG appeared to be associated with elevated risk of gastric cancer, but not within the highest category of 1-OHPG (Q4 vs Q1: OR = 1.4; 95% CI = 0.8-2.5). CONCLUSIONS: Our findings suggest that higher concentrations of 1-OHPG are related to gastric cancer risk, but no clear dose-response relationship was observed.
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Authors | Linda M Liao, Jonathan N Hofmann, Farin Kamangar, Paul T Strickland, Bu-Tian Ji, Gong Yang, Hong-Lan Li, Nathaniel Rothman, Wei Zheng, Wong-Ho Chow, Yu-Tang Gao, Xiao-Ou Shu |
Journal | International journal of molecular epidemiology and genetics
(Int J Mol Epidemiol Genet)
Vol. 5
Issue 3
Pg. 140-4
( 2014)
ISSN: 1948-1756 [Print] United States |
PMID | 25379133
(Publication Type: Journal Article)
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