Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus.

Abstract

EVER1 and EVER2 are mutated in epidermodysplasia verruciformis patients, who are susceptible to human betapapillomavirus (HPV) infection. It is unknown whether their products control the infection of other viruses. Here, we show that the expression of both genes in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed via activation of the NF-κB signaling pathway by latent membrane protein 1 (LMP1). Ectopic expression of EVER1 impairs the ability of EBV to infect B cells.

• Authors: Cecilia Frecha, Sébastien A Chevalier, Patrick van Uden, Ivonne Rubio, Maha Siouda, Djamel Saidj, Camille Cohen, Patrick Lomonte, Rosita Accardi, Massimo Tommasino
• Journal: Journal of virology (J Virol) Vol. 89 Issue 2 Pg. 1461-7 (Jan 15 2015) ISSN: 1098-5514 [Electronic] United States
• PMID: 25378492 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Chemical References

• EBV-associated membrane antigen, Epstein-Barr virus
• Membrane Proteins
• TMC6 protein, human
• TMC8 protein, human
• Viral Matrix Proteins

Topics

• B-Lymphocytes (virology)
• Epidermodysplasia Verruciformis (pathology)
• Gene Expression Regulation
• Herpesvirus 4, Human (physiology)
• Host-Pathogen Interactions
• Humans
• Membrane Proteins (biosynthesis, genetics)
• Viral Matrix Proteins (metabolism)