Abstract | INTRODUCTION:
Injuries to the CNS represent a major global health problem. CNS injuries cause the elevation of many proteins, including innate immune proteins in biological fluids, such as the cerebrospinal fluid (CSF). These innate immune proteins can be considered as biomarkers to predict the severity of CNS injury in patients. AREAS COVERED: EXPERT OPINION: Although inflammasome proteins may be of great clinical significance in the near future, a more detailed analysis of inflammasome proteins needs to be taken into account for the prognosis and treatment of diverse CNS conditions. Moreover, the potential inflammasome biomarker candidates have to be validated in a large number of patients for an extended period post-injury to further support clinical relevance.
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Authors | Mithilesh Kumar Jha, Ho-Won Lee, Sang Yun Kim, Kyoungho Suk |
Journal | Expert opinion on therapeutic patents
(Expert Opin Ther Pat)
Vol. 25
Issue 2
Pg. 241-5
(Feb 2015)
ISSN: 1744-7674 [Electronic] England |
PMID | 25377183
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Inflammasomes
- Proteins
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Topics |
- Biomarkers
(metabolism)
- Central Nervous System
(immunology, injuries, physiopathology)
- Central Nervous System Diseases
(immunology, physiopathology)
- Humans
- Immunity, Innate
- Inflammasomes
(metabolism)
- Patents as Topic
- Prognosis
- Proteins
(metabolism)
- Trauma Severity Indices
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