Abstract | OBJECTIVE: DESIGN: Prospective observational cohort study. We used the number of days alive and free of mechanical ventilation on day 28 as a composite outcome measure and used multivariable ordinal logistic regression analyses to adjust for potential confounders. SETTING: ICUs of two tertiary care hospitals in The Netherlands. PATIENTS: INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Over a 2-year period, 306 patients were included, 209 (68%) of whom were cytomegalovirus seropositive. Cytomegalovirus reactivation occurred in 53 of these cases (26%). One hundred patients (33%) died or continued to be mechanically ventilated by day 28. After adjustment for confounding, cytomegalovirus seroprevalence was not associated with the primary outcome (crude odds ratio, 1.09; 95% CI, 0.70-1.70; adjusted odds ratio, 1.01; 95% CI, 0.64-1.59). Seroprevalence was also not associated with poor outcome in any of the prespecified subgroup analyses. However, a significant association was found in a post hoc subgroup of patients who had developed acute respiratory distress syndrome in a setting of septic shock (adjusted odds ratio, 2.86; 95% CI, 1.32-6.23). The time course of pulmonary markers in survivors was comparable between the two serogroups. CONCLUSIONS:
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Authors | David S Y Ong, Peter M C Klein Klouwenberg, Frans M Verduyn Lunel, Cristian Spitoni, Jos F Frencken, Huberta A T Dekker, Marcus J Schultz, Marc J M Bonten, Olaf L Cremer |
Journal | Critical care medicine
(Crit Care Med)
Vol. 43
Issue 2
Pg. 394-400
(Feb 2015)
ISSN: 1530-0293 [Electronic] United States |
PMID | 25377020
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Antiviral Agents
(administration & dosage, therapeutic use)
- Carrier State
(drug therapy)
- Chemoprevention
- Critical Illness
- Cytomegalovirus Infections
(drug therapy, epidemiology)
- Female
- Hospital Mortality
- Humans
- Immunocompromised Host
- Intensive Care Units
- Male
- Middle Aged
- Netherlands
(epidemiology)
- Prospective Studies
- Respiration, Artificial
- Respiratory Distress Syndrome
(epidemiology, mortality)
- Risk Factors
- Seroepidemiologic Studies
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