Severe hyperpigmentation and scarring following glycolic acid peel treatment in combination with low-dose isotretinoin.

Abstract

BACKGROUND:

The application of systemic isotretinoin in the treatment of cutaneous photoaging has been well investigated. In addition, well-recognized topical antiaging therapies such as superficial chemical peeling (CP) with α-hydroxy acids have been shown to be more helpful when combined with low-dose oral isotretinoin. Even though the combination of systemic isotretinoin and medium to deep CP has been associated with serious side effects such as delayed wound healing and enlarged incidence of scarring, to date superficial CP and concomitant systemic isotretinoin have been considered safe.

CASE PRESENTATION:

In this report, we present the case of a patient receiving low-dose oral isotretinoin therapy who developed severe painful erythema and erosions that led to permanent hyperpigmentation and scarring of her face and neck after undergoing superficial CP with glycolic acid.

CONCLUSIONS:

There is a potential risk of hyperpigmentation and scarring with the use of a combination of low-dose oral isotretinoin and glycolic acid peeling.

• Authors: Peter Arne Gerber, Gabriela Kukova, Edwin Bölke, Bernhard Homey, Evelyn Diedrichson
• Journal: European journal of medical research (Eur J Med Res) Vol. 19 Pg. 60 (Nov 07 2014) ISSN: 2047-783X [Electronic] England
• PMID: 25376482 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glycolates
• glycolic acid
• Isotretinoin

Topics

• Administration, Oral
• Adult
• Cicatrix (diagnosis, drug therapy)
• Drug Therapy, Combination (methods)
• Female
• Glycolates (administration & dosage, therapeutic use)
• Humans
• Hyperpigmentation (diagnosis, drug therapy)
• Isotretinoin (administration & dosage, therapeutic use)