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[A case of hepatocellular carcinoma (HCC) with lung metastasis which responded to chemotherapy with a single use of 1-hexylcarbamoyl-5-fluorouracil (HCFU)].

Abstract
To our knowledge, there has been only one report pertaining to the efficacy of HCFU for treatment of metastatic lung lesion of HCC, so we reported a case of HCC with lung metastasis which responded to chemotherapy with a single use of HCFU. A 64-year-old male was diagnosed as having HCC with lung metastasis by biochemical examination, abdominal CT, hepatic arteriogram and chest X-P. He had been treated previously with gamma-interferon and mitoxantrone, which were assessed as NC and PD, respectively. Two months after last chemotherapy, HCFU was administrated at a dose of 400 mg/body everyday for 8 months. After 4 weeks metastatic lung lesions showed remarkable regression (47% decrease) and disappeared completely 9 weeks later. The size of primary liver tumor gradually decreased during therapy and revealed marked improvement (85.7% decrease) after about 2 months of this therapy. During these periods serum levels of alpha-fetoprotein dropped from 430 ng/ml to less than 10 ng/ml. He is presently still alive and the duration of the PR attained to 35 weeks. As side effects, hypoproteinemia, anorexia and hot sensation were observed.
AuthorsY Kanda, S Akazawa, K Futatsugi, T Fujiki, K Saifuku, K Yamamoto, F Suzuki, T Nakajima, Y Naoi, M Muraoka
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 16 Issue 2 Pg. 269-72 (Feb 1989) ISSN: 0385-0684 [Print] Japan
PMID2537606 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
  • carmofur
  • Fluorouracil
Topics
  • Antineoplastic Agents (administration & dosage, therapeutic use)
  • Carcinoma, Hepatocellular (drug therapy, secondary)
  • Fluorouracil (administration & dosage, analogs & derivatives, therapeutic use)
  • Humans
  • Liver Neoplasms (drug therapy, pathology)
  • Lung Neoplasms (drug therapy, secondary)
  • Male
  • Middle Aged
  • Remission Induction

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