Abstract |
To our knowledge, there has been only one report pertaining to the efficacy of HCFU for treatment of metastatic lung lesion of HCC, so we reported a case of HCC with lung metastasis which responded to chemotherapy with a single use of HCFU. A 64-year-old male was diagnosed as having HCC with lung metastasis by biochemical examination, abdominal CT, hepatic arteriogram and chest X-P. He had been treated previously with gamma-interferon and mitoxantrone, which were assessed as NC and PD, respectively. Two months after last chemotherapy, HCFU was administrated at a dose of 400 mg/body everyday for 8 months. After 4 weeks metastatic lung lesions showed remarkable regression (47% decrease) and disappeared completely 9 weeks later. The size of primary liver tumor gradually decreased during therapy and revealed marked improvement (85.7% decrease) after about 2 months of this therapy. During these periods serum levels of alpha-fetoprotein dropped from 430 ng/ml to less than 10 ng/ml. He is presently still alive and the duration of the PR attained to 35 weeks. As side effects, hypoproteinemia, anorexia and hot sensation were observed.
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Authors | Y Kanda, S Akazawa, K Futatsugi, T Fujiki, K Saifuku, K Yamamoto, F Suzuki, T Nakajima, Y Naoi, M Muraoka |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 16
Issue 2
Pg. 269-72
(Feb 1989)
ISSN: 0385-0684 [Print] Japan |
PMID | 2537606
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- carmofur
- Fluorouracil
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Topics |
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Carcinoma, Hepatocellular
(drug therapy, secondary)
- Fluorouracil
(administration & dosage, analogs & derivatives, therapeutic use)
- Humans
- Liver Neoplasms
(drug therapy, pathology)
- Lung Neoplasms
(drug therapy, secondary)
- Male
- Middle Aged
- Remission Induction
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