Abstract | OBJECTIVE: METHOD AND MATERIAL: A total of 78 neonates were included in the study. After randomization, intervention group received nebulization with Budesonide (0.5 mg dissolved in 2.5-ml sterile normal saline within 2 h of birth and second dose was given at 12 h of birth) whereas controls were nebulized with normal saline. All neonates were accessed for serial respiratory distress score (Downe's score), requirement (dependence) of oxygen (in days), duration of neonatal intensive-care unit (NICU) stay, any complication and their final outcome. RESULTS: The mean days of oxygen requirement for the cases and controls were 1.79 and 3.46, respectively (p < 0.001). The mean respiratory rate in intervention group up to the age of 5 d was significantly less (p value < 0.01). There was significant difference in mean Downe's score and mean duration of NICU stay in intervention group. CONCLUSION:
Budesonide nebulization in meconium aspiration results in significant early improvement in general condition (early improvement in respiratory distress and early normalization of Downe's score) of the newborn with lesser oxygen requirement, thus early discharge from NICU but has no impact on final outcome.
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Authors | Neelmani Garg, Mukesh Choudhary, Deepak Sharma, Dhanraj Dabi, Jagveer Singh Choudhary, Sushil Kumar Choudhary |
Journal | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
(J Matern Fetal Neonatal Med)
Vol. 29
Issue 1
Pg. 36-40
( 2016)
ISSN: 1476-4954 [Electronic] England |
PMID | 25373430
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Glucocorticoids
- Budesonide
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Topics |
- Administration, Inhalation
- Budesonide
(administration & dosage)
- Female
- Glucocorticoids
(administration & dosage)
- Humans
- Infant, Newborn
- Male
- Meconium Aspiration Syndrome
(drug therapy)
- Respiratory Function Tests
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