Abstract | PURPOSE: METHODS: A cross-sectional study of 50 adult men with SCD ( hemoglobin SS) was performed. All patients had early morning blood taken for total and free testosterone, FSH, LH, prolactin, lipid levels, LDH and hematological indices. Patients completed an interviewer-administered questionnaire regarding priapism frequency, duration and treatment. Testosterone deficiency was defined as a serum total testosterone<12 nmol/L (346 ng/dL). RESULTS: The mean age of the study population was 34.2±8.9 years. Priapism was noted in 24 (48%) patients and was most frequently seen in men between ages 18-25 years. Testosterone deficiency was observed in 11 of the 50 (22%) patients, particularly in 6 of 24 (25%) patients with histories of priapism. There was no difference in mean total testosterone levels in patients with and without a history of priapism (16.7±4.9 nmol/L and 15.4±5.9 nmol/L, respectively) (p=0.43). Similarly, there was no difference in serum LH and FSH levels based on history of priapism. CONCLUSION:
Testosterone deficiency is prevalent in patients with SCD; however, we did not identify an association based on a history of priapism. Larger, prospectively gathered data are needed to define the priapism profile of SCD patients with testosterone deficiency.
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Authors | Belinda F Morrison, Uzoma A Anele, Marvin E Reid, Wendy A Madden, Zhaoyong Feng, Arthur L Burnett |
Journal | International urology and nephrology
(Int Urol Nephrol)
Vol. 47
Issue 1
Pg. 47-52
(Jan 2015)
ISSN: 1573-2584 [Electronic] Netherlands |
PMID | 25371242
(Publication Type: Journal Article)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Triglycerides
- Testosterone
- Luteinizing Hormone
- Follicle Stimulating Hormone
- L-Lactate Dehydrogenase
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Topics |
- Adolescent
- Adult
- Anemia, Sickle Cell
(blood, complications)
- Blood Cell Count
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Cross-Sectional Studies
- Follicle Stimulating Hormone
(blood)
- Humans
- L-Lactate Dehydrogenase
(blood)
- Luteinizing Hormone
(blood)
- Male
- Middle Aged
- Priapism
(blood, complications)
- Risk Factors
- Testosterone
(blood, deficiency)
- Triglycerides
(blood)
- Young Adult
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