Vitamin D binding protein gene polymorphism as a risk factor for vitamin D deficiency in Thais.

Abstract

OBJECTIVE:

Vitamin D deficiency is related to increased risks for a number of diseases. To date, at least 3 candidate genes, vitamin D binding protein (VDBP) gene (GC), 25-hydroxylase (CYP2R1), and 7-dehydrocholesterol reductase/NAD synthetase 1 (DHCR7/NADSYN1), have been associated with serum 25-hydroxyvitamin D (25[OH]D) levels, but their influences on the prevalence of vitamin D deficiency in relation to other known risk factors have not been clearly defined.

METHODS:

The study assessed 4,476 individuals aged 14 to 93 years from the Thailand 4th National Health Examination Survey (2008-2009) and the Electricity Generating Authority of Thailand (EGAT) (2008) cohorts. The GC rs2282679 polymorphism on chromosome 4q12-q13 was genotyped by real-time polymerase chain reaction (PCR). Serum 25(OH)D was measured by liquid chromatography/tandem mass spectrometry. Vitamin D deficiency was defined as a 25(OH)D concentration <20 ng/mL.

RESULTS:

Data were expressed as mean ± SD. There were 2,747 (61.4%) males and 1,729 (38.6%) females in the study, with an average body mass index (BMI) of 23.7 ± 4.2 kg/m2 and a mean total 25(OH)D of 28.9 ± 9.0 ng/mL. Serum 25(OH)D levels decreased progressively with the presence of the C allele. Using multiple logistic regression analysis, vitamin D deficiency was significantly associated with the GC rs2282679 genotype (odds ratio [OR] per C allele 1.80, 95% confidence interval CI 1.57-2.01), independent of established risk factors for vitamin D deficiency including age, sex, and BMI.

CONCLUSION:

A specific GC gene polymorphism is associated with lower 25(OH)D levels independent of age, sex, and adiposity in Thai subjects.

• Authors: Pranee Thongthai, La-or Chailurkit, Suwannee Chanprasertyothin, Hataikarn Nimitphong, Piyamitr Sritara, Wichai Aekplakorn, Boonsong Ongphiphadhanakul
• Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists (Endocr Pract) Vol. 21 Issue 3 Pg. 221-5 (Mar 2015) ISSN: 1530-891X [Print] United States
• PMID: 25370324 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vitamin D-Binding Protein
• Vitamin D
• 25-hydroxyvitamin D

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Asian People (genetics)
• Female
• Genotype
• Humans
• Logistic Models
• Male
• Middle Aged
• Polymorphism, Genetic
• Risk Factors
• Vitamin D (analogs & derivatives, blood)
• Vitamin D Deficiency (etiology, genetics)
• Vitamin D-Binding Protein (genetics)