HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor β1.

Abstract
Ubiquitin specific protease 22 (USP22) is an oncogene that is upregulated in many cancer types, and aberrant expression of USP22 correlates with clinical outcome. However, its potential functional impact in epithelial ovarian cancer (EOC) has not been determined. Here, we report that USP22 was upregulated in EOC specimens and EOC cell lines with important functional consequences. A high level of USP22 in EOC tissues was associated with advanced clinical FIGO stage, lymph node metastasis and worse prognosis. Patients with higher USP22 expression had shorter relapse-free and overall survival. Depletion of USP22 suppressed cell proliferation in vitro and tumor growth in vivo. We found that inhibition of USP22 suppressed cell proliferation by inducing G1 phase cell cycle arrest through synergy with oncogenic transforming growth factor-β1 (TGFB1). Our results indicate that USP22 functions as an oncogene in EOC, and thus USP22 may serve as a potential therapeutic target for individualized EOC treatment.
AuthorsMei Ji, Huirong Shi, Ya Xie, Zhao Zhao, Shunshuang Li, Cheng Chang, Xinghan Cheng, Yue Li
JournalOncology reports (Oncol Rep) Vol. 33 Issue 1 Pg. 133-40 (Jan 2015) ISSN: 1791-2431 [Electronic] Greece
PMID25369910 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • TGFB1 protein, human
  • Transforming Growth Factor beta1
  • Thiolester Hydrolases
  • Ubiquitin Thiolesterase
  • Usp22 protein, human
Topics
  • Animals
  • Carcinogenesis (metabolism)
  • Carcinoma, Ovarian Epithelial
  • Cell Line, Tumor
  • Cell Proliferation
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Gene Expression
  • Humans
  • Mice, Inbred BALB C
  • Mice, Nude
  • Middle Aged
  • Neoplasms, Glandular and Epithelial (enzymology, mortality, pathology)
  • Ovarian Neoplasms (enzymology, mortality, pathology)
  • Prognosis
  • Signal Transduction
  • Thiolester Hydrolases (physiology)
  • Transforming Growth Factor beta1 (physiology)
  • Tumor Burden
  • Ubiquitin Thiolesterase

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: