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Drug-induced subacute cutaneous lupus erythematosus associated with docetaxel chemotherapy: a case report.

AbstractBACKGROUND:
Drug-induced subacute cutaneous lupus erythematosus is an uncommon disorder associated with the use of pharmacological agents including systemic chemotherapy.
CASE PRESENTATION:
We report a case of docetaxel-induced subacute cutaneous lupus erythematosus in a 60-year-old Caucasian female with Sjögren's syndrome diagnosed 2 months after receiving docetaxel as part of the adjuvant FEC-D (5-fluorouracil, epirubicin, cyclophosphamide, docetaxel) chemotherapy protocol for early stage breast cancer. Although the exact mechanisms behind the autoimmune response elicited by docetaxel are unclear, the involvement of anti-SSA/Ro antibodies has been implicated.
CONCLUSION:
This case highlights the symptom severity and clinical course of docetaxel-induced subacute cutaneous lupus erythematosus, and highlights the importance of recognizing this uncommon but potentially severe chemotherapy-associated cutaneous reaction.
AuthorsNoelle Y Wong, Laurie M Parsons, Martin J Trotter, Roger Y Tsang
JournalBMC research notes (BMC Res Notes) Vol. 7 Pg. 785 (Nov 05 2014) ISSN: 1756-0500 [Electronic] England
PMID25369825 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Antinuclear
  • SS-A antibodies
  • Taxoids
  • Docetaxel
Topics
  • Antibodies, Antinuclear (blood)
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects)
  • Biopsy
  • Breast Neoplasms (drug therapy, pathology)
  • Docetaxel
  • Drug Eruptions (diagnosis, etiology, immunology, therapy)
  • Female
  • Humans
  • Lupus Erythematosus, Cutaneous (chemically induced, diagnosis, immunology, therapy)
  • Middle Aged
  • Neoplasm Staging
  • Severity of Illness Index
  • Sjogren's Syndrome (immunology)
  • Taxoids (administration & dosage, adverse effects)
  • Treatment Outcome

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