Abstract | BACKGROUND: Urothelial carcinoma (UC) variants can be difficult to differentiate from carcinoma metastatic to the bladder. MATERIALS AND METHODS: We examined immunostaining for uroplakin III in 43 cases of primary bladder UC variants including micropapillary UC (n=19), nested variant of UC (n=2), pleomorphic giant-cell carcinoma (n=8), plasmacytoid UC (n=4), lymphoepithelioma-like carcinoma (n=2), large cell undifferentiated carcinoma (n=2), UC with abundant myxoid stroma (n=3) and lipid cell variant (n=3) and in 11 tumors from other organs metastatic to the bladder. These tumors included invasive ductal carcinoma of the breast (n=2), colorectal adenocarcinoma (n=4), endometrioid adenocarcinoma (n=1) and serous papillary carcinoma of the uterus (n=1) melanoma (n=1), embryonal carcinoma of the testis (n=1), and renal clear cell carcinoma (n=1). RESULTS: CONCLUSION: UP III Positivity for uroplakin III is not found only in primary bladder UC variants, but in some tumors that have metastatized to the bladder. Staining for uroplakin III alone should not be taken as evidence of UC.
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Authors | Kiara Klopfer, Brett Delahunt, Michael Adamson, Hemamali Samaratunga |
Journal | Anticancer research
(Anticancer Res)
Vol. 34
Issue 11
Pg. 6779-84
(Nov 2014)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 25368291
(Publication Type: Journal Article)
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Copyright | Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- Uroplakin III
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Giant Cell
(metabolism, secondary)
- Carcinoma, Large Cell
(metabolism, secondary)
- Carcinoma, Papillary
(metabolism, secondary)
- Female
- Follow-Up Studies
- Humans
- Immunoenzyme Techniques
- Male
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Staging
- Prognosis
- Urinary Bladder Neoplasms
(metabolism, pathology)
- Uroplakin III
(metabolism)
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