Efficacy of nab-paclitaxel does not seem to be associated with SPARC expression in metastatic breast cancer.

Abstract

AIM:

To evaluate the predictive value of the expression of the secreted protein acidic and rich in cysteine (SPARC) for nab-paclitaxel in metastatic breast cancer (MBC).

PATIENTS AND METHODS:

Forty-four patients with progressive MBC were prospectively treated with nab-paclitaxel. Expression of SPARC in tumor cells was assessed by an immunoreactive score, integrating staining intensity and percentage of positive tumor cells; expression in stroma based on staining intensity. SPARC serum levels were determined before 1st and 2nd cycle of nab-paclitaxel and at progression. By applying several cut-offs the association between SPARC expression or serum levels and clinical end-points was analyzed.

RESULTS:

No clear association between expression of SPARC in primary or metastatic tumor tissue or in serum and any clinical end-point could be detected regardless of the various cut-offs applied.

CONCLUSION:

Efficacy of nab-paclitaxel in MBC does not seem to be associated with expression of SPARC in tumor tissues or serum.

• Authors: Andreas Schneeweiss, Julia Seitz, Katharina Smetanay, Florian Schuetz, Dirk Jaeger, Andreas Bachinger, Markus Zorn, Hans-Peter Sinn, Frederik Marmé
• Journal: Anticancer research (Anticancer Res) Vol. 34 Issue 11 Pg. 6609-15 (Nov 2014) ISSN: 1791-7530 [Electronic] Greece
• PMID: 25368265 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• 130-nm albumin-bound paclitaxel
• Albumins
• Biomarkers, Tumor
• Osteonectin
• SPARC protein, human
• Paclitaxel

Topics

• Adult
• Aged
• Albumins (administration & dosage)
• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (drug therapy, mortality, secondary)
• Dose-Response Relationship, Drug
• Enzyme-Linked Immunosorbent Assay
• Female
• Follow-Up Studies
• Humans
• Immunoenzyme Techniques
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Staging
• Osteonectin (metabolism)
• Paclitaxel (administration & dosage)
• Prognosis
• Prospective Studies
• Survival Rate