Seizure freedom after lamotrigine rash: a peculiar phenomenon in epilepsy.

Abstract

A 57-year-old right-handed woman with a history of left frontal lobe stroke had experienced episodes of language-expression difficulty followed by paraphasia lasting for approximately 30 seconds two years earlier. She was diagnosed with left frontal lobe epilepsy, and a lamotrigine regimen was initiated. This treatment had to be stopped five weeks after initiation because she developed a rash, and her drug lymphocyte stimulation test result was positive. Interestingly, she has since remained seizure free without requiring any antiepileptic medications. This adult case with a peculiar clinical course provides support for the hypothesis of immunomodulation process involvement in epilepsy, a phenomenon that was previously mainly seen in pediatric patients.

• Authors: Yosuke Kakisaka, Kazutaka Jin, Kazuhiro Kato, Masaki Iwasaki, Nobukazu Nakasato
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 53 Issue 21 Pg. 2521-2 ( 2014) ISSN: 1349-7235 [Electronic] Japan
• PMID: 25366014 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Triazines
• Lamotrigine

Topics

• Anticonvulsants (adverse effects)
• Drug Eruptions (etiology)
• Epilepsy, Frontal Lobe (drug therapy, etiology)
• Exanthema (chemically induced)
• Female
• Humans
• Lamotrigine
• Middle Aged
• Stroke (complications)
• Triazines (adverse effects)