Abstract | BACKGROUND: METHODS: We allocated 21 patients aged 50 to 84 years who underwent total hip replacement surgery. Releases of TNF-α, IL-1β, IL-6, IL-8 and IL-10 and protrombin fragment F1.2 and plasmin- antiplasmin complex (PAP) were examined during surgery and up 6 days postoperatively, and systemic releases were compared to pre-operative values. Surgery induced significant increments in serum levels of IL-6 at 6 hours and at 1 day after surgery and in levels of IL-8 at 6 hours after surgery. There were no significant changes in serum levels of TNF-α, IL-1β or IL-10. There were significant increments in blood levels of F1.2 and PAP up to 6 days postoperatively with highest levels at 6 hours after surgery. There were only week correlations between IL-6 and IL-8 and F1.2 and PAP. CONCLUSION: Major musculoskeletal surgery causes changes of the inflammatory, coagulatory and fibrinolytic cascades in stable patients, but with no correlations between inflammation and coagulation and fibrinolysis.
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Authors | Olav Reikerås, Pål Borgen |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 11
Pg. e107881
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25364904
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Cytokines
- Inflammation Mediators
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Blood Coagulation
- Cytokines
(blood)
- Female
- Fibrinolysis
- Humans
- Inflammation
(blood, etiology)
- Inflammation Mediators
(blood)
- Male
- Middle Aged
- Musculoskeletal System
(injuries)
- Risk Factors
- Surgical Procedures, Operative
(adverse effects)
- Time Factors
- Wounds and Injuries
(blood, complications, etiology)
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