HMGA proteins as modulators of chromatin structure during transcriptional activation.

Abstract

High mobility group (HMG) proteins are the most abundant non-histone chromatin associated proteins. HMG proteins bind to DNA and nucleosome and alter the structure of chromatin locally and globally. Accessibility to DNA within chromatin is a central factor that affects DNA-dependent nuclear processes, such as transcription, replication, recombination, and repair. HMG proteins associate with different multi-protein complexes to regulate these processes by mediating accessibility to DNA. HMG proteins can be subdivided into three families: HMGA, HMGB, and HMGN. In this review, we will focus on recent advances in understanding the function of HMGA family members, specifically their role in gene transcription regulation during development and cancer.

• Authors: Nihan Ozturk, Indrabahadur Singh, Aditi Mehta, Thomas Braun, Guillermo Barreto
• Journal: Frontiers in cell and developmental biology (Front Cell Dev Biol) Vol. 2 Pg. 5 ( 2014) ISSN: 2296-634X [Print] Switzerland
• PMID: 25364713 (Publication Type: Journal Article, Review)