BPTF Associated with EMT Indicates Negative Prognosis in Patients with Hepatocellular Carcinoma.

Abstract

BACKGROUND/AIMS:

Epithelial-mesenchymal transition (EMT) plays an important role in hepatocellular carcinoma (HCC) dissemination. Bromodomain PHD-finger transcription factor (BPTF) could regulate embrogenesis and stem cell differentiation, and it may be involved in tumor progression and EMT. In this study, we aimed to determine BPTF, E-cadherin and vimentin expression in tumor tissues and the clinical significance in relation to HCC.

METHODS:

The BPTF, vimentin and E-cadherin expression of 106 HCC tissue samples was examined by immunohistochemical staining.

RESULTS:

BPTF and vimentin showed high expression and E-cadherin showed low expression in HCC. BPTF is associated with the tumor number, vascular invasion, Edmondson-Steiner grade, TNM stage and recurrence (P < 0.05). Vimentin is positively correlated with tumor size, tumor number, vascular invasion, Edmondson-Steiner grade, TNM stage and recurrence (P < 0.05). E-cadherin is negatively correlated with tumor number, Edmondson-Steiner grade, TNM stage and recurrence (P < 0.05). Survival analysis has shown that high expression of BPTF and vimentin indicates poorer overall and disease-free survival (P < 0.05). Multivariate analysis shows that BPTF is an independent marker for survival prediction (P = 0.015). Additionally, high BPTF expression is correlated with high vimentin expression and low E-cadherin expression (P < 0.05).

CONCLUSION:

High BPTF expression may be an independent marker for survival prediction in HCC patients and is probably involved in EMT.

• Authors: Shuai Xiao, Longfei Liu, Min Fang, Xiaojun Zhou, Xiuda Peng, Jianwu Long, Xianzhou Lu
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 60 Issue 4 Pg. 910-8 (Apr 2015) ISSN: 1573-2568 [Electronic] United States
• PMID: 25362514 (Publication Type: Journal Article)

Chemical References

• Antigens, Nuclear
• Biomarkers, Tumor
• Cadherins
• Nerve Tissue Proteins
• Transcription Factors
• Vimentin
• fetal Alzheimer antigen

Topics

• Adult
• Aged
• Aged, 80 and over
• Antigens, Nuclear (metabolism)
• Biomarkers, Tumor (metabolism)
• Cadherins (metabolism)
• Carcinoma, Hepatocellular (metabolism, mortality, pathology)
• China (epidemiology)
• Epithelial-Mesenchymal Transition
• Female
• Follow-Up Studies
• Humans
• Liver Neoplasms (metabolism, mortality, pathology)
• Male
• Middle Aged
• Nerve Tissue Proteins (metabolism)
• Prognosis
• Transcription Factors (metabolism)
• Vimentin (metabolism)
• Young Adult