Chronic myelogenous leukemia, version 1.2015.

Abstract

Chronic myelogenous leukemia (CML) is usually diagnosed in the chronic phase. Untreated chronic phase CML will eventually progress to advanced phase (accelerated or blast phase) CML. Tyrosine kinase inhibitors (TKIs) have been shown to induce favorable response rates in patients with accelerated and blast phase CML. The addition of TKIs to chemotherapy has also been associated with improved outcomes in patients with blast phase CML. Allogeneic hematopoietic stem cell transplant remains a potentially curative option for patients with advanced phase CML, although treatment with a course of TKIs will be beneficial as a bridge to transplant. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with advanced phase CML.

• Authors: Susan O'Brien, Jerald P Radich, Camille N Abboud, Mojtaba Akhtari, Jessica K Altman, Ellin Berman, Peter Curtin, Daniel J DeAngelo, Michael Deininger, Steven Devine, Amir T Fathi, Jason Gotlib, Madan Jagasia, Patricia Kropf, Joseph O Moore, Arnel Pallera, Vishnu Vb Reddy, Neil P Shah, B Douglas Smith, David S Snyder, Meir Wetzler, Kristina Gregory, Hema Sundar
• Journal: Journal of the National Comprehensive Cancer Network : JNCCN (J Natl Compr Canc Netw) Vol. 12 Issue 11 Pg. 1590-610 (Nov 2014) ISSN: 1540-1413 [Electronic] United States
• PMID: 25361806 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 by the National Comprehensive Cancer Network.

Chemical References

• Antineoplastic Agents
• Protein Kinase Inhibitors
• Protein-Tyrosine Kinases

Topics

• Antineoplastic Agents (therapeutic use)
• Guidelines as Topic
• Hematopoietic Stem Cell Transplantation (methods)
• Humans
• Leukemia, Myeloid, Accelerated Phase (diagnosis, drug therapy, surgery)
• Leukemia, Myeloid, Chronic-Phase (diagnosis, drug therapy, surgery)
• Protein Kinase Inhibitors (therapeutic use)
• Protein-Tyrosine Kinases (antagonists & inhibitors)