Efficacy of pentoxifylline and tadalafil in rat model of ischemic colitis.

Abstract

OBJECTIVE:

The aim of this study is to investigate the efficacy of tadalafil against pentoxifylline in rat model of ischemic colitis (IC).

MATERIAL-METHODS:

Thirty-two Wistar albino rats were subjected to laparotomy and left colon devascularization to create an IC model and then randomly placed into four groups. Group-1 (sham group) was administered 0.9% NaCl following laparotomy, group 2 (control group) was administered 0.9% NaCl following induced IC, group 3 was given pentoxifylline (n = 8), and group 4 was given tadalafil. On the third day; macroscopic findings, Gomella's ischemic area and Wallace scoring, histopathological analysis, and Chiu scoring were performed, and malondialdehyde (MDA) measurement in ischemic colon tissue was carried out through chemical analysis.

RESULTS:

Significant differences were observed in acidic fluid, bowel dilatation, and serosal change (p < .05). The ischemic area measured 63.3 mm(2) in the control group, 2.8 mm(2) in the pentoxifylline group (p = .0001), and 2.4 mm(2) (p = .0001) in the tadalafil group. A significant difference was seen between the sham group and the control and pentoxifylline groups (p < .01), in terms of Wallace score and Chiu classification. Similarly, a significant difference was determined between the control group and pentoxifylline and tadalafil groups (p < .01), but no significant difference was established between the pentoxifylline group and tadalafil group (p = .33). MDA measurement was found on an average to be 63.7 in the control group, 22.7 in group 3 and 22.8 in group 4 (p = 001).

CONCLUSION:

Although tadalafil is superior to pentoxifylline, both drugs are considered to have positive effects.

• Authors: Enver Reyhan, Oktay Irkorucu, Ali Surmelioglu, Selvinaz Ozkara, Kamuran Cumhur Deger, Mehmet Aziret, Hasan Erdem, Suleyman Cetinkunar, Pelin Demirturk, Ahmet Ozer Sehirli
• Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research (J Invest Surg) Vol. 27 Issue 6 Pg. 349-53 (Dec 2014) ISSN: 1521-0553 [Electronic] United States
• PMID: 25361018 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Carbolines
• Phosphodiesterase 5 Inhibitors
• Platelet Aggregation Inhibitors
• Malondialdehyde
• Tadalafil
• Pentoxifylline

Topics

• Animals
• Carbolines (therapeutic use)
• Colitis, Ischemic (drug therapy, etiology)
• Colon (metabolism, surgery)
• Disease Models, Animal
• Female
• Laparotomy
• Malondialdehyde (metabolism)
• Pentoxifylline (therapeutic use)
• Phosphodiesterase 5 Inhibitors (therapeutic use)
• Platelet Aggregation Inhibitors (therapeutic use)
• Rats
• Rats, Wistar
• Tadalafil
• Treatment Outcome