Ursolic acid inhibits superoxide production in activated neutrophils and attenuates trauma-hemorrhage shock-induced organ injury in rats.

Abstract

Neutrophil activation is associated with the development of organ injury after trauma-hemorrhagic shock. In the present study, ursolic acid inhibited the superoxide anion generation and elastase release in human neutrophils. Administration of ursolic acid attenuated trauma-hemorrhagic shock-induced hepatic and lung injuries in rats. In addition, administration of ursolic acid attenuated the hepatic malondialdehyde levels and reduced the plasma aspartate aminotransferase and alanine aminotransferase levels after trauma-hemorrhagic shock. In conclusion, ursolic acid, a bioactive natural compound, inhibits superoxide anion generation and elastase release in human neutrophils and ameliorates trauma-hemorrhagic shock-induced organ injury in rats.

• Authors: Tsong-Long Hwang, Hsin-I Shen, Fu-Chao Liu, Hsin-I Tsai, Yang-Chang Wu, Fang-Rong Chang, Huang-Ping Yu
• Journal: PloS one (PLoS One) Vol. 9 Issue 10 Pg. e111365 ( 2014) ISSN: 1932-6203 [Electronic] United States
• PMID: 25360589 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Triterpenes
• Superoxides
• Pancreatic Elastase
• ursolic acid

Topics

• Animals
• Humans
• Liver (drug effects, immunology, injuries)
• Lung Injury (drug therapy, etiology, immunology)
• Male
• Neutrophil Activation (drug effects)
• Neutrophils (drug effects, immunology, metabolism)
• Pancreatic Elastase (metabolism)
• Rats
• Rats, Sprague-Dawley
• Shock, Hemorrhagic (complications)
• Superoxides (metabolism)
• Triterpenes (pharmacology, therapeutic use)