Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation.

Abstract

KEY CLINICAL MESSAGE:

Neurotoxic snake envenomation can result in respiratory failure and death. Early treatment is considered important to survival. Inexpensive, heat-stable, needle-free, antiparalytics could facilitate early treatment of snakebite and save lives, but none have been developed. An experiment using aerosolized neostigmine to reverse paralysis suggests how early interventions could be developed.

• Authors: Matthew R Lewin, Philip Bickler, Tom Heier, John Feiner, Lance Montauk, Brett Mensh
• Journal: Clinical case reports (Clin Case Rep) Vol. 1 Issue 1 Pg. 7-15 (Oct 2013) ISSN: 2050-0904 [Print] England
• PMID: 25356201 (Publication Type: Journal Article)