Renal development process in human is divided into 3 successive stages: pronephros, mesonephros, and metanephros. The tubules continue to mature for 1-2 year after birth. Research of urinary
proteome during human renal development is still lacking. Most urine
proteome studies focus on postnatal renal maturation period. A comparison between full-term infant and adult urinary
protein pattern identified 648 infant-enriched
protein spots, of which most were involved in cellular turnover and metabolism. The study of preterm infant urinary
proteome compared with term infants suggests elevated
IGFBP-1,
IGFBP-2, and
IGFBP-6,
monocyte chemotactic protein-1, CD14, and
sialic acid-binding Ig-like lectin 5 during nephrogenesis. Research in several congenital kidney and urinary tract anomalies, ureteropelvic junction obstruction and
autosomal dominant polycystic kidney disease, has discovered novel
biomarkers, which may help to imply the mechanisms underlying inherited disorders. Future exploration of urinary
proteome evolution during renal maturation is needed and will help to find novel
biomarkers specially suiting pediatric renal diseases.