[Application of serum thymidine kinase 1 of 26 055 cases in health screening for early detection of premalignant/early malignant tumors].

To determine the application of serum thymidine kinase 1 (STK1) in general health screening for early detection of premalignant/early malignant tumors.
A cross sectional study was carried out in 26 055 health screenings from 8 centers of Changsha in 2011. The concentration of STK1 was determined by a sensitive chemiluminescent dot blot ECL assay.
In the elevated STK1 group 60.35% showed diseases with a higher risk of premalignant/ early cancerous progression. The positive rate of elevated STK1 (>2.0 pmol/L) was 2.61%. There was a significantly higher rate with moderate/severe type of hyperplasia of breasts and prostate with elevated STK1 than people with normal STK1 values.
STK1 may be a reliable marker for risk assessment of premalignant/early malignant tumors.
AuthorsXia Cao, Yaqin Wang, Pingting Yang, Hui Zhou, Chang Liu, Zhiheng Chen
JournalZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 39 Issue 10 Pg. 1029-34 (Oct 2014) ISSN: 1672-7347 [Print] China
PMID25355255 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • Thymidine Kinase
  • thymidine kinase 1
  • Biomarkers, Tumor (blood)
  • Breast (pathology)
  • Cross-Sectional Studies
  • Early Detection of Cancer
  • Female
  • Humans
  • Hyperplasia
  • Male
  • Neoplasms (diagnosis)
  • Precancerous Conditions (diagnosis)
  • Prostate (pathology)
  • Thymidine Kinase (blood)

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