Abstract | BACKGROUND:
Spiradenoma and cylindroma have historically been described as sweat gland tumors and have often been considered to be of eccrine lineage. However, (a) associations with trichoepitheliomas in Brooke-Spiegler syndrome or with trichoepitheliomas and milia in Rasmussen syndrome, (b) neoplastic combinations with hair follicle tumors in solitary cases, and (c) anatomical considerations support a folliculosebaceous-apocrine lineage. Follicular stem cell markers may allow for further characterization of these neoplasms. METHODS: RESULTS: CONCLUSIONS: It is concluded that both spiradenoma and cylindroma are not eccrine but follicular tumors. More specifically, it is proposed that both adnexal neoplasms are derived from the hair follicle bulge and as such represent one of the least differentiated follicular tumors.
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Authors | Klaus Sellheyer |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 42
Issue 2
Pg. 90-101
(Feb 2015)
ISSN: 1600-0560 [Electronic] United States |
PMID | 25354097
(Publication Type: Journal Article)
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Copyright | © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Antigens, CD
- Biomarkers, Tumor
- Keratin-15
- antigens, CD200
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD
(analysis, metabolism)
- Biomarkers, Tumor
(analysis, metabolism)
- Carcinoma, Adenoid Cystic
(metabolism, pathology)
- Eccrine Glands
(metabolism, pathology)
- Female
- Hair Follicle
(metabolism, pathology)
- Humans
- Immunohistochemistry
- Keratin-15
(metabolism)
- Male
- Middle Aged
- Neoplastic Stem Cells
(metabolism, pathology)
- Skin
(metabolism, pathology)
- Sweat Gland Neoplasms
(metabolism, pathology)
- Sweat Glands
(metabolism, pathology)
- Young Adult
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