Cardiac calcium score on 2D echo: correlations with cardiac and coronary calcium at multi-detector computed tomography.

Abstract

BACKGROUND:

To test the hypothesis that a semi-quantitative echocardiographic calcium score (eCS) significantly correlates with cardiac calcium measured by coronary computed tomography angiography (CCTA) and, secondarily, severe coronary artery calcifications and stenosis.

METHODS:

This is a retrospective, observational study, conducted in a tertiary centre. eCS was compared with CCTA scores of non-coronary cardiac calcium (nCACS), coronary cardiac calcium (CACS) and number of diseased coronary vessels, in 141 subjects without known coronary artery disease (CAD), who underwent both echocardiography and CCTA for clinical reasons.

RESULTS:

Age, prevalence of hypertension and all measures of calcium (eCS, nCACS and CACS) differed significantly between the no-CAD and CAD subgroups. eCS was positively correlated with nCACS (Spearman rho = 0.64, p < 0.0001), CACS (rho = 0.46, p < 0.01) and weakly with the number of diseased coronary vessels (rho = 0.28, p < 0.05). eCS and nCACS had similar area under the curve (AUC) for the prediction of severe CACS (≥400) (0.77, 95% CI 0.68-0.86 and 0.79, 95% CI 0.72-0.88) or obstructive CAD (0.63, 95% CI 0.54-0.72 and 0.63, 95% CI 0.55-0.73).

CONCLUSIONS:

eCS, a calcium score easily obtainable during standard echocardiography, is moderately to strongly correlated with nCACS by CCTA. The full eCS score correlates with nCACS better than its single components. It correlates with CACS and predicts severe coronary calcification (CACS > 400), a known predictor of cardiovascular morbidity and mortality. The eCS also predicts obstructive CAD, incrementally to age and clinical variables, although for this purpose CACS remains the most accurate score.

• Authors: Nicola Gaibazzi, Chiara Baldari, Pompilio Faggiano, Lisa Albertini, Giacomo Faden, Filippo Pigazzani, Cristina Rossi, Claudio Reverberi
• Journal: Cardiovascular ultrasound (Cardiovasc Ultrasound) Vol. 12 Pg. 43 (Oct 28 2014) ISSN: 1476-7120 [Electronic] England
• PMID: 25352208 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Topics

• Aged
• Calcinosis (complications, diagnosis)
• Coronary Stenosis (diagnostic imaging, etiology)
• Echocardiography (methods)
• Female
• Humans
• Image Interpretation, Computer-Assisted (methods)
• Male
• Middle Aged
• Multidetector Computed Tomography (methods)
• Observer Variation
• Reproducibility of Results
• Sensitivity and Specificity
• Statistics as Topic