[Immune response to plasma-derived hepatitis B vaccine in hospital health personnel of Parma].

Abstract

In January 1984 a hepatitis B vaccination campaign was started in health care workers of Hospital of Parma. Within 3 years, of the 953 subjects submitted to serologic screening, 446 were eligible and 409, serum negative for HBV, completed the vaccination. 202 received HB-VAX vaccine (M.S.D.) intramusculary into the buttock at 0.1 and 6 months, and 208 received HEVAC-B vaccine (Pasteur) into deltoid region at 0, 1, 2 and 12 months. After the booster injection, percent of seroconversion (anti-HBs greater than 10 UI/l) and anti-HBs antibody titres were significantly (p less than 0.01) higher in HEVAC-B recipients (95.6%, mean anti-HBs titres = 6400 UI/l), than in the subjects vaccined with HB-VAX (77.1%, mean anti-HBs titres = 2703 UI/l). There was no significative difference in immune response in both groups with respect to age, sex or occupational category. Three hepatitis B infections were identified in HB-VAX recipients, but no one in individuals vaccined with HEVAC-B. No participants had serious adverse effects, minor side effects occurred with equal frequency in both groups. In general, both plasma-derived vaccines have proved to be highly immunogenic, safe and well tolerated in health care workers, however HEVAC-B vaccine, since contains S and pre-S ag, has shown a more satisfactory immunogenic effect.

• Authors: G Magnani, A Bertoletti, C Calzetti, M Campari, P Pizzaferri, C Schianchi, P Vitali
• Journal: Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma (Acta Biomed Ateneo Parmense) Vol. 60 Issue 1-2 Pg. 73-9 ( 1989) Italy
• Vernacular Title: Risposta immune ai vaccini plasma-derivati anti epatite B nel personale sanitario ospedaliero di Parma.
• PMID: 2535096 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Hepatitis B Antibodies
• Hepatitis B Vaccines
• Vaccines, Synthetic
• Viral Hepatitis Vaccines

Topics

• Adult
• Female
• Hepatitis B Antibodies (analysis)
• Hepatitis B Vaccines
• Humans
• Immunization, Secondary
• Italy
• Male
• Middle Aged
• Occupations
• Personnel, Hospital
• Vaccines, Synthetic (immunology)
• Viral Hepatitis Vaccines (immunology)