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How D-dimer assay can be useful in deciding the duration of anticoagulation after venous thromboembolism: a review.

Abstract
Venous thromboembolism has a relatively strong tendency to recur, especially when the event is unprovoked. In this case, the duration of anticoagulation should not be shorter than 3 months, but it is also suggested to be indefinite. The decision to discontinue or extend indefinitely anticoagulation is not easy. D-dimer assay has a predictive value for individual risk of recurrence and can therefore be used in the decision-making process regarding duration of anticoagulation. This article reviews studies on D-dimer measurement as a predictor of the recurrence risk and analyzes the results of a very recent clinical study (the DULCIS study) that investigated how D-dimer assay can effectively and safely be used to decide the duration of anticoagulation in individual patients after an unprovoked event.
AuthorsGualtiero Palareti
JournalExpert review of hematology (Expert Rev Hematol) Vol. 8 Issue 1 Pg. 79-88 (Feb 2015) ISSN: 1747-4094 [Electronic] England
PMID25348806 (Publication Type: Journal Article, Review)
Chemical References
  • Anticoagulants
  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D
Topics
  • Anticoagulants (administration & dosage)
  • Drug Administration Schedule
  • Fibrin Fibrinogen Degradation Products (analysis)
  • Humans
  • Risk Factors
  • Venous Thromboembolism (blood, drug therapy)

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