Abstract |
Venous thromboembolism has a relatively strong tendency to recur, especially when the event is unprovoked. In this case, the duration of anticoagulation should not be shorter than 3 months, but it is also suggested to be indefinite. The decision to discontinue or extend indefinitely anticoagulation is not easy. D-dimer assay has a predictive value for individual risk of recurrence and can therefore be used in the decision-making process regarding duration of anticoagulation. This article reviews studies on D-dimer measurement as a predictor of the recurrence risk and analyzes the results of a very recent clinical study (the DULCIS study) that investigated how D-dimer assay can effectively and safely be used to decide the duration of anticoagulation in individual patients after an unprovoked event.
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Authors | Gualtiero Palareti |
Journal | Expert review of hematology
(Expert Rev Hematol)
Vol. 8
Issue 1
Pg. 79-88
(Feb 2015)
ISSN: 1747-4094 [Electronic] England |
PMID | 25348806
(Publication Type: Journal Article, Review)
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Chemical References |
- Anticoagulants
- Fibrin Fibrinogen Degradation Products
- fibrin fragment D
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Topics |
- Anticoagulants
(administration & dosage)
- Drug Administration Schedule
- Fibrin Fibrinogen Degradation Products
(analysis)
- Humans
- Risk Factors
- Venous Thromboembolism
(blood, drug therapy)
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