Abstract |
The aim of this study was to assess prospectively 2-year outcomes of transoral incisionless fundoplication (TIF) in a multicenter setting. A 14-center U.S. registry was designed to evaluate the effects of the TIF 2.0 procedure on chronic gastroesophageal reflux disease ( GERD) in over 100 patients. Primary outcome was symptom assessment. Secondary outcomes were proton pump inhibitor (PPI) use, degree of esophagitis, safety, and changes in esophageal acid exposure. One hundred twenty-seven patients underwent TIF between January 2010 and April 2011, 19 (15%) of whom were lost to follow-up. Eight patients undergoing revisional surgery were included, as failures, in the 108 remaining patients. No serious adverse events were reported. GERD Health-related Quality of Life and regurgitation scores improved by 50 per cent or greater in 63 of 96 (66%) and 62 of 88 (70%) patients who had elevated preoperative scores. The Reflux Symptom Index score normalized in 53 of 82 (65%) patients. Daily PPI use decreased from 91 to 29 per cent. In patients amenable to postoperative testing, esophagitis healed in 12 of 16 (75%) and esophageal acid exposure normalized in eight of 14 (57%). TIF safely achieved sustained symptomatic control over a 2-year period in two-thirds of patients with a virtual absence of de novo side effects.
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Authors | Reginald C W Bell, William E Barnes, Bart J Carter, Robert W Sewell, Peter G Mavrelis, Glenn M Ihde, Kevin M Hoddinott, Mark A Fox, Katherine D Freeman, Tanja Gunsberger, Mark G Hausmann, David Dargis, Brian DaCosta Gill, Erik Wilson, Karim S Trad |
Journal | The American surgeon
(Am Surg)
Vol. 80
Issue 11
Pg. 1093-105
(Nov 2014)
ISSN: 1555-9823 [Electronic] United States |
PMID | 25347499
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Esophagitis
(etiology, surgery)
- Female
- Fundoplication
(methods)
- Gastroesophageal Reflux
(complications, surgery)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Proton Pump Inhibitors
(therapeutic use)
- Quality of Life
- Registries
- Reoperation
- Severity of Illness Index
- Surveys and Questionnaires
- Treatment Outcome
- United States
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