Abstract |
The efficacy of josamycin in the treatment of inflammatory acne has been evaluated in 39 patients. Josamycin was orally administered to the patients as a single 500 mg daily dose for two months, but the patients with the most severe lesions received an initial treatment of 1 g for a maximum of 20 days. All subjects received josamycin in combination with other antiacne drugs mostly benzoyl peroxide ointment. The treatment induced a significant regression of the number and the severity of the lesions scored according to Plewig-Kligman's classification. At the end of the treatment a positive effect was observed for 92% of the subjects, independently of the variety and the degree of the severity of the disease. According to the patients' judgments josamycin was an effective treatment (92.3%) and more effective that the previously prescribed drugs (95%). Only 1 patient reported the occurrence of a side effect (mild gastric discomfort). Josamycin showed in this study to be an effective and safe drug for the treatment of inflammatory acne.
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Authors | S Bundino, R Salomone, A M Zina |
Journal | Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
(G Ital Dermatol Venereol)
1989 Nov-Dec
Vol. 124
Issue 11-12
Pg. LV-LX
ISSN: 0392-0488 [Print] Italy |
Vernacular Title | Valutazione clinica della josamicina nella terapia dell'acne. |
PMID | 2534716
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Acne Vulgaris
(drug therapy)
- Adolescent
- Adult
- Drug Administration Schedule
- Drug Evaluation
- Female
- Humans
- Josamycin
(administration & dosage, therapeutic use)
- Male
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