Comparative trial of moisturizer containing spent grain wax, Butyrospermum parkii extract, Argania spinosa kernel oil vs. 1% hydrocortisone cream in the treatment of childhood atopic dermatitis.

Abstract

OBJECTIVE:

To compare an efficacy of a moisturizer containing spent grain wax, Butyrospermum parkii extract, Argania spinosa kernel oil (S) with 1% hydrocortisone cream (HC) for the treatment of mild to moderate atopic dermatitis.

MATERIAL AND METHOD:

Twenty-nine patients, age between 2 and 15 years old with mild to moderate atopic dermatitis were enrolled The body was randomly divided to left and right side. One side was applied with S cream and the other side was applied with HC cream twice daily for four weeks. Observation of recurrence rate after remission was recorded. Clinical outcomes were analyzed by using the scoring ofAtopic Dermatitis (SCORAD) score. Statistical analysis was done by using descriptive statistics, pair t-test, one-way repeated ANOVA, and McNemar's test.

RESULTS:

It was demonstrated that both agents had improvement of SCORAD score after two weeks, with statistically significant difference (p< 0. 001). At fourth week, both agents had improvement of SCORAD score without being statistically significant different (p>0.05). Although the S cream side had higher remission rate than the HC cream side, there was no statistically significant difference (p> 0. 05).

CONCLUSION:

S cream was as effective as HC cream in the treatment and maintenance period of mild to moderate childhood atopic dermatitis.

• Authors: Panaya Jirabundansuk, Suwirakorn Ophaswongse, Montree Udompataikul
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 97 Issue 8 Pg. 820-6 (Aug 2014) ISSN: 0125-2208 [Print] Thailand
• PMID: 25345257 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• hydrocortisone acetate
• Hydrocortisone

Topics

• Administration, Cutaneous
• Child
• Child, Preschool
• Dermatitis, Atopic (drug therapy)
• Edible Grain (chemistry)
• Female
• Humans
• Hydrocortisone (administration & dosage, analogs & derivatives, therapeutic use)
• Male
• Recurrence
• Sapotaceae (chemistry)
• Severity of Illness Index
• Single-Blind Method
• Treatment Outcome